Civil WarTimeline of Missouri History: 1673-1799
| 1673 | During their voyage down the Mississippi River, Father Jacques Marquette and Louis Joliet were the first Europeans to set foot on land that would later become Missouri | |
| 1682 | Explorer Robert Cavalier, Sieur de La Salle took possession of the Louisiana Territory area for France (Apr. 9) |
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| 1724 | Fort Orleans built on the north bank of the Missouri River by Etienne de Bourgmont in today’s Carroll County; it was abandoned six years later | |
| 1750 | Approximate date of the founding of Ste. Genevieve, the first permanent white settlement | |
| 1762 | Spain gained control of the Louisiana Territory in the Treaty of Fontainebleau (Nov. 13) | |
| 1764 | City of St. Louis was founded by Pierre Laclede Liguest (Feb. 15) | |
| 1769 | City of St. Charles was established by Louis Blanchette as a trading post | |
| 1770 | The Spanish government officially assumed control of the Territory of Louisiana (May 20) | |
| 1773 | Mine au Breton (later Potosi) founded | |
| 1789 | Colonel George Morgan established the city of New Madrid (Feb. 14) | |
| 1793 | Louis Lorimer received trading privileges and authority to establish a post at Cape Girardeau (Jan. 4) | |
| 1798 | Lieutenant Governor Zenon Trudeau of the Spanish government offered Daniel Boone 1000 arpents to settle in the Louisiana Territory | |
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